Noni fruit leaf extract can delay fatigue

November 18, 2022

Previously, the extract of Noni fruit was very famous and even considered to be the next super fruit. Many supplement companies then introduced a variety of 0 noni fruit extract supplements, cosmetics and food, but the market reaction was dull.

For a long time, people's interest in Noni fruit has been concentrated on fruits and juices, while Malaysian researchers have only studied the extract of Noni fruit leaves, and finally found that this ingredient can prolong the swimming time of weight-bearing swimming mice.
The noni fruit leaf in the trial was provided by the University of Putra, Malaysia, and the researchers added it to distilled water for three hours to obtain the noni fruit extract. The green tea water extract in the test contained 95% polyphenols, 5% caffeine and 40% gallagechin gallate.
The researchers then selected female mice for 6-7 months to test the basic swimming time. The mice were then randomized into 5 groups: the first group received 200 mg of noni fruit extract, the second group was 400 mg, the third group was 200 mg of green tea extract, and the fourth group received assisted training. The last group does not participate in the training, but still has assistance.

The training method used in the test is called the weight-bearing swimming test, which is to assess the swimming endurance of the mouse by recording the time from the start of swimming to exhaustion. The test is conducted once a week for four weeks. As the test progressed, each rat's tail was tied to its own weight of 5%, and then forced to swim until the exhaustion was flooded. After the end of the swimming test, the researchers obtained blood samples from the rats by cardiac puncture, and then frozen the skeletal muscle and liver tissues of the rats separately for experimental analysis.

The results of the study showed that the 200 mg and 400 mg noni fruit extracts extended the swimming time of the mice by 40% and 28% in the first week and the swimming time in the second week by 20% compared with the control group. 14%, the third week of swimming time extended by 50% and 41%. At the same time, the researchers found that the extract of Noni fruit leaves had no significant effect on blood glucose and lactate levels in mice, although the swimming time of these two groups of mice was three times higher than that of the other groups. In addition, there was no significant difference in skeletal muscle and liver tissue between the two groups of mice.

Researchers say that Noni leaf water extracts may be able to relieve fatigue through central and peripheral mechanisms. During the movement of the mouse, glucose supplies energy and lactic acid is the main metabolite. The researchers found that noni fruit extract not only enhances the endurance of mammals, but also improves the nutritional and metabolic regulation of animal tissues (researchers speculate that this may be related to angiogenesis), inhibits the release of stress hormones, and regulates neurotransmission. The level of transport increases the biological activity of mitochondria, increases skeletal muscle angiogenesis, and promotes anti-inflammatory responses.

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